My anecdotal understandings from reading various sources are; 1. The virus breaks down the barrier between the upper and lower respiratory systems allowing bacteria to penetrate the Alveoli. 2. There are some folks immune systems that “overreact” to the novel virus causing people to be compromised by their own immune reaction. 3. This virus (probably like any virus) really hits people with comorbidities hard. 4. Certain factors (e.g. smoking, pollution, age) make people more vulnerable. 5. There may be additional risk to a heavy exposure.
My understanding of the best guess why hydroxychloroquine might be effective on some is its immunosuppressant characteristic and not its antiparasitic one. This begs the question in my mind that IF this is true, then in those with an overactive immune system would a milder immunosuppressant drug (like a steroid) work as well?
Are there other vulnerabilities such as blood type?
You are right, we are guessing without a massive and repeated testing effort.
Things will not get back to normal without 1. a treatment and 2. a vaccine. This virus may become seasonal and a 2nd wave in the fall/winter is possible.
Regardless things will change on the other side of this. I believe an “onshoring” effect of manufacturing strategic goods (e.g. toilet paper) will happen. People will work remotely more. People will stockpile more. The big boat cruise ship industry may not survive. Air travel will be reduced. Internet will become a utility. Probably many other changes….
-Tony
Date: Wed, 8 Apr 2020 08:21:37 -0400
From: Tony Blake
Subject: RE: Iceland response and findings